Comparing cardiac troponin levels using sevoflurane and isoflurane in patients undergoing cardiac surgery: a systematic review and meta-analysis
Identifieur interne : 000662 ( Main/Exploration ); précédent : 000661; suivant : 000663Comparing cardiac troponin levels using sevoflurane and isoflurane in patients undergoing cardiac surgery: a systematic review and meta-analysis
Auteurs : Hossein Hosseinifard [Iran] ; Nashmil Ghadimi [Iran] ; Sara Kaveh [Iran] ; Hossein Shabaninejad [Iran, Royaume-Uni] ; Alaadine Lijassi [Maroc] ; Rasoul Azarfarin [Iran]Source :
- Journal of Cardiovascular and Thoracic Research [ 2008-5117 ] ; 2020.
Abstract
Url:
DOI: 10.34172/jcvtr.2020.01
PubMed: 32211131
PubMed Central: 7080340
Affiliations:
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comparing cardiac troponin levels using sevoflurane and isoflurane in patients undergoing cardiac surgery: a systematic review and meta-analysis</title>
<author><name sortKey="Hosseinifard, Hossein" sort="Hosseinifard, Hossein" uniqKey="Hosseinifard H" first="Hossein" last="Hosseinifard">Hossein Hosseinifard</name>
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<author><name sortKey="Ghadimi, Nashmil" sort="Ghadimi, Nashmil" uniqKey="Ghadimi N" first="Nashmil" last="Ghadimi">Nashmil Ghadimi</name>
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<country xml:lang="fr">Iran</country>
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<author><name sortKey="Kaveh, Sara" sort="Kaveh, Sara" uniqKey="Kaveh S" first="Sara" last="Kaveh">Sara Kaveh</name>
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<author><name sortKey="Shabaninejad, Hossein" sort="Shabaninejad, Hossein" uniqKey="Shabaninejad H" first="Hossein" last="Shabaninejad">Hossein Shabaninejad</name>
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<country xml:lang="fr">Royaume-Uni</country>
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<author><name sortKey="Lijassi, Alaadine" sort="Lijassi, Alaadine" uniqKey="Lijassi A" first="Alaadine" last="Lijassi">Alaadine Lijassi</name>
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<author><name sortKey="Azarfarin, Rasoul" sort="Azarfarin, Rasoul" uniqKey="Azarfarin R" first="Rasoul" last="Azarfarin">Rasoul Azarfarin</name>
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<series><title level="j">Journal of Cardiovascular and Thoracic Research</title>
<idno type="ISSN">2008-5117</idno>
<idno type="eISSN">2008-6830</idno>
<imprint><date when="2020">2020</date>
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<front><div type="abstract" xml:lang="en"><p><italic><bold>Introduction:</bold>
</italic>
Cardiac troponin is one of the heart biomarkers and its high levels correlates with a high risk of cardiomyocytes damage. This study aimed to compare sevoflurane and isoflurane effect on troponin levels in patients undergoing cardiac surgery. </p>
<p><italic><bold> Methods: </bold>
</italic>
We systematically searched for RCTs which had been published in Cochrane library, PubMed, Web of science, CRD, Scopus, and Google Scholar by the end of February 30th, 2019. The quality of articles was evaluated with the Cochrane checklist. GRADE was used for quality of evidence for this meta-analysis. Meta-analysis was done based on random or fixed effect model.</p>
<p><italic><bold> Results:</bold>
</italic>
Five studies with total of 190 (sevoflurane) and 191 (isoflurane) patients were included. The results showed that pooled mean difference of troponin levels between the two groups was significant at ICU admission time and 24 hours after entering. The comparison of troponin level changes between the two groups (baseline = at time ICU) in 24 and 48 hours after ICU admission was significant. </p>
<p><italic><bold>Conclusion:</bold>
</italic>
This meta-analysis showed that blood troponin levels were significantly lower at the time of arrival in ICU with isoflurane and after 24 hours with sevoflurane. Generally, given the small mean difference between isoflurane and sevoflurane, it seems that none of the medications has a negative effect on the cardiac troponin level.</p>
</div>
</front>
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